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Inhibition of gene expression in human cells using RNase P-derived ribozymes and external guide sequences
Ribonuclease P (RNase P) complexed with an external guide sequence (EGS) represents a novel nucleic acid-based gene interference approach to modulate gene expression. This enzyme is a ribonucleoprotein complex for tRNA processing. In E. coli, RNase P contains a catalytic RNA subunit (M1 ribozyme) an...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2705784/ https://ncbi.nlm.nih.gov/pubmed/17976837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbaexp.2007.09.001 |
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