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Population Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs

Little information exists on the pulmonary pharmacology of antituberculosis drugs. We used population pharmacokinetic modeling and Monte Carlo simulation to describe and explore the pulmonary pharmacokinetics and pharmacodynamics of rifampin (RIF; rifampicin). A population pharmacokinetic model that...

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Autori principali: Goutelle, Sylvain, Bourguignon, Laurent, Maire, Pascal H., Van Guilder, Michael, Conte, John E., Jelliffe, Roger W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704682/
https://ncbi.nlm.nih.gov/pubmed/19380594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01520-08
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