Population Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs

Little information exists on the pulmonary pharmacology of antituberculosis drugs. We used population pharmacokinetic modeling and Monte Carlo simulation to describe and explore the pulmonary pharmacokinetics and pharmacodynamics of rifampin (RIF; rifampicin). A population pharmacokinetic model that...

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Bibliographic Details
Main Authors: Goutelle, Sylvain, Bourguignon, Laurent, Maire, Pascal H., Van Guilder, Michael, Conte, John E., Jelliffe, Roger W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704682/
https://ncbi.nlm.nih.gov/pubmed/19380594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01520-08
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