Population Modeling and Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Isoniazid in Lungs

Among first-line antituberculosis drugs, isoniazid (INH) displays the greatest early bactericidal activity (EBA) and is key to reducing contagiousness in treated patients. The pulmonary pharmacokinetics and pharmacodynamics of INH have not been fully characterized with modeling and simulation approa...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Lalande, L., Bourguignon, L., Bihari, S., Maire, P., Neely, M., Jelliffe, R., Goutelle, S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538517/
https://ncbi.nlm.nih.gov/pubmed/26077251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00462-15
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