Population Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs

Little information exists on the pulmonary pharmacology of antituberculosis drugs. We used population pharmacokinetic modeling and Monte Carlo simulation to describe and explore the pulmonary pharmacokinetics and pharmacodynamics of rifampin (RIF; rifampicin). A population pharmacokinetic model that...

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Bibliografiske detaljer
Main Authors: Goutelle, Sylvain, Bourguignon, Laurent, Maire, Pascal H., Van Guilder, Michael, Conte, John E., Jelliffe, Roger W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704682/
https://ncbi.nlm.nih.gov/pubmed/19380594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01520-08
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