Effect of Rifampin, a Potent Inducer of Drug-Metabolizing Enzymes, on the Pharmacokinetics of Raltegravir

Raltegravir is a human immunodeficiency virus type 1 integrase strand transfer inhibitor that is metabolized by glucuronidation via UGT1A1 and may be affected by inducers of UGT1A1, such as rifampin (rifampicin). Two pharmacokinetic studies were performed in healthy subjects: study 1 examined the ef...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Wenning, Larissa A., Hanley, William D., Brainard, Diana M., Petry, Amelia S., Ghosh, Kalyan, Jin, Bo, Mangin, Eric, Marbury, Thomas C., Berg, Jolene K., Chodakewitz, Jeffrey A., Stone, Julie A., Gottesdiener, Keith M., Wagner, John A., Iwamoto, Marian
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology (ASM) 2009
الموضوعات:
Pharmacology
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704654/
https://ncbi.nlm.nih.gov/pubmed/19433563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01468-08
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