Effect of Rifampin, a Potent Inducer of Drug-Metabolizing Enzymes, on the Pharmacokinetics of Raltegravir

Raltegravir is a human immunodeficiency virus type 1 integrase strand transfer inhibitor that is metabolized by glucuronidation via UGT1A1 and may be affected by inducers of UGT1A1, such as rifampin (rifampicin). Two pharmacokinetic studies were performed in healthy subjects: study 1 examined the ef...

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Autors principals: Wenning, Larissa A., Hanley, William D., Brainard, Diana M., Petry, Amelia S., Ghosh, Kalyan, Jin, Bo, Mangin, Eric, Marbury, Thomas C., Berg, Jolene K., Chodakewitz, Jeffrey A., Stone, Julie A., Gottesdiener, Keith M., Wagner, John A., Iwamoto, Marian
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704654/
https://ncbi.nlm.nih.gov/pubmed/19433563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01468-08
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