Lack of a Clinically Important Effect of Moderate Hepatic Insufficiency and Severe Renal Insufficiency on Raltegravir Pharmacokinetics

Raltegravir is a human immunodeficiency virus type 1 integrase strand transfer inhibitor with potent activity in vitro and in vivo. Raltegravir is primarily cleared by hepatic metabolism via glucuronidation (via UDP glucuronosyltransferase 1A1), with a minor component of elimination occurring via th...

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Detalhes bibliográficos
Main Authors: Iwamoto, Marian, Hanley, William D., Petry, Amelia S., Friedman, Evan J., Kost, James T., Breidinger, Sheila A., Lasseter, Kenneth C., Robson, Richard, Lunde, Norman M., Wenning, Larissa A., Stone, Julie A., Wagner, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681501/
https://ncbi.nlm.nih.gov/pubmed/19223645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01194-08
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