Lack of a Clinically Important Effect of Moderate Hepatic Insufficiency and Severe Renal Insufficiency on Raltegravir Pharmacokinetics

Raltegravir is a human immunodeficiency virus type 1 integrase strand transfer inhibitor with potent activity in vitro and in vivo. Raltegravir is primarily cleared by hepatic metabolism via glucuronidation (via UDP glucuronosyltransferase 1A1), with a minor component of elimination occurring via th...

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Bibliografske podrobnosti
Main Authors: Iwamoto, Marian, Hanley, William D., Petry, Amelia S., Friedman, Evan J., Kost, James T., Breidinger, Sheila A., Lasseter, Kenneth C., Robson, Richard, Lunde, Norman M., Wenning, Larissa A., Stone, Julie A., Wagner, John A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681501/
https://ncbi.nlm.nih.gov/pubmed/19223645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01194-08
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