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Amyloid precursor protein transgenic mouse models and Alzheimer’s disease: Understanding the paradigms, limitations and contributions
Transgenic (Tg) mice overexpressing mutant familial Alzheimer’s disease (AD) amyloid precursor protein (APP) genes have contributed to the understanding of dementia pathology and support the amyloid cascade hypothesis. Although many sophisticated mice APP models exist, none recapitulates AD cellular...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2704491/ https://ncbi.nlm.nih.gov/pubmed/19560104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2009.03.002 |
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