Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study

PURPOSE: To assess the safety and efficacy of neoadjuvant bevacizumab with standard chemoradiotherapy in locally advanced rectal cancer and explore biomarkers for response. PATIENTS AND METHODS: In a phase I/II study, 32 patients received four cycles of therapy consisting of: bevacizumab infusion (5...

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Hlavní autoři: Willett, Christopher G., Duda, Dan G., di Tomaso, Emmanuelle, Boucher, Yves, Ancukiewicz, Marek, Sahani, Dushyant V., Lahdenranta, Johanna, Chung, Daniel C., Fischman, Alan J., Lauwers, Gregory Y., Shellito, Paul, Czito, Brian G., Wong, Terence Z., Paulson, Erik, Poleski, Martin, Vujaskovic, Zeljko, Bentley, Rex, Chen, Helen X., Clark, Jeffrey W., Jain, Rakesh K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2009
Témata:
Original Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702234/
https://ncbi.nlm.nih.gov/pubmed/19470921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.21.1771
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