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Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

The effects of vascular endothelial growth factor (VEGF) blockade on the vascular biology of human tumors are not known. Here we show here that a single infusion of the VEGF-specific antibody bevacizumab decreases tumor perfusion, vascular volume, microvascular density, interstitial fluid pressure a...

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Detalhes bibliográficos
Main Authors: Willett, Christopher G, Boucher, Yves, di Tomaso, Emmanuelle, Duda, Dan G, Munn, Lance L, Tong, Ricky T, Chung, Daniel C, Sahani, Dushyant V, Kalva, Sanjeeva P, Kozin, Sergey V, Mino, Mari, Cohen, Kenneth S, Scadden, David T, Hartford, Alan C, Fischman, Alan J, Clark, Jeffrey W, Ryan, David P, Zhu, Andrew X, Blaszkowsky, Lawrence S, Chen, Helen X, Shellito, Paul C, Lauwers, Gregory Y, Jain, Rakesh K
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693485/
https://ncbi.nlm.nih.gov/pubmed/14745444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm988
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