Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study

PURPOSE: To assess the safety and efficacy of neoadjuvant bevacizumab with standard chemoradiotherapy in locally advanced rectal cancer and explore biomarkers for response. PATIENTS AND METHODS: In a phase I/II study, 32 patients received four cycles of therapy consisting of: bevacizumab infusion (5...

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Autors principals: Willett, Christopher G., Duda, Dan G., di Tomaso, Emmanuelle, Boucher, Yves, Ancukiewicz, Marek, Sahani, Dushyant V., Lahdenranta, Johanna, Chung, Daniel C., Fischman, Alan J., Lauwers, Gregory Y., Shellito, Paul, Czito, Brian G., Wong, Terence Z., Paulson, Erik, Poleski, Martin, Vujaskovic, Zeljko, Bentley, Rex, Chen, Helen X., Clark, Jeffrey W., Jain, Rakesh K.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Clinical Oncology 2009
Matèries:
Original Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702234/
https://ncbi.nlm.nih.gov/pubmed/19470921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.21.1771
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