Direct Evidence that Bevacizumab, an Anti-VEGF Antibody, Up-regulates SDF1α, CXCR4, CXCL6, and Neuropilin 1 in Tumors from Patients with Rectal Cancer

Clinical studies converge on the observation that circulating cytokines are elevated in most cancer patients by anti– vascular endothelial growth factor (VEGF) therapy. However, the source of these molecules and their relevance in tumor escape remain unknown. We examined the gene expression profiles...

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Detalhes bibliográficos
Main Authors: Xu, Lei, Duda, Dan G., di Tomaso, Emmanuelle, Ancukiewicz, Marek, Chung, Daniel C., Lauwers, Gregory Y., Samuel, Rekha, Shellito, Paul, Czito, Brian G., Lin, Pei-Chun, Poleski, Martin, Bentley, Rex, Clark, Jeffrey W., Willett, Christopher G., Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859041/
https://ncbi.nlm.nih.gov/pubmed/19826039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2099
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