In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene

Major limitations to gene therapy using HSCs are low gene transfer efficiency and the inability of most therapeutic genes to confer a selective advantage on the gene-corrected cells. One approach to enrich for gene-modified cells in vivo is to include in the retroviral vector a drug resistance gene,...

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Autori principali: Larochelle, Andre, Choi, Uimook, Shou, Yan, Naumann, Nora, Loktionova, Natalia A., Clevenger, Joshua R., Krouse, Allen, Metzger, Mark, Donahue, Robert E., Kang, Elizabeth, Stewart, Clinton, Persons, Derek, Malech, Harry L., Dunbar, Cynthia E., Sorrentino, Brian P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701865/
https://ncbi.nlm.nih.gov/pubmed/19509470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37506
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