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Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis
The phosphatidylinositol 3-kinase (PI3K)/AKT pathway is frequently upregulated in human cancer. Activation of this pathway has been reported to be associated with resistance to various chemotherapeutical agents. We here used a chemical biology/chemical informatic approach to identify apoptotic mecha...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Springer-Verlag
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701489/ https://ncbi.nlm.nih.gov/pubmed/19568785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12154-009-0017-7 |
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