Mutant Presenilin-1 Induces Apoptosis and Downregulates Akt/PKB

Most early onset cases of familial Alzheimer’s disease (AD) are caused by mutations in presenilin-1 (PS1) and presenilin-2 (PS2). These mutations lead to increased β-amyloid formation and may induce apoptosis in some model systems. Using primary cultured hippocampal neurons (HNs) and rat pheochromoc...

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Xehetasun bibliografikoak
Argitaratua izan da:J Neurosci
Egile Nagusiak: Weihl, Conrad C., Ghadge, Ghanashyam D., Kennedy, Scott G., Hay, Nissim, Miller, Richard J., Roos, Raymond P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 1999
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782321/
https://ncbi.nlm.nih.gov/pubmed/10377346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-13-05360.1999
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