Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis

The p53 protein activates cellular death programs through multiple pathways. Because the high frequency of p53 mutations in human tumors is believed to contribute to resistance to commonly used chemotherapeutic agents, it is important to identify drugs that induce p53-independent cell death and to d...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Erdal, Hamdiye, Berndtsson, Maria, Castro, Juan, Brunk, Ulf, Shoshan, Maria C., Linder, Stig
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544072/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15618392/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408592102
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