Lysosomal destabilization in p53-induced apoptosis

The tumor suppressor wild-type p53 can induce apoptosis. M1-t-p53 myeloid leukemic cells have a temperature-sensitive p53 protein that changes its conformation to wild-type p53 after transfer from 37°C to 32°C. We have now found that these cells showed an early lysosomal rupture after transfer to 32...

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Bibliographic Details
Main Authors: Yuan, Xi-Ming, Li, Wei, Dalen, Helge, Lotem, Joseph, Kama, Rachel, Sachs, Leo, Brunk, Ulf T.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC122941/
https://ncbi.nlm.nih.gov/pubmed/11959917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.092135599
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