Specific Residues of RUNX2 Are Obligatory for Formation of BMP2-Induced RUNX2-SMAD Complex to Promote Osteoblast Differentiation

BMP2 signaling and RUNX2 regulatory pathways converge for transcriptional control of bone formation in vivo. SMAD proteins are recruited to RUNX2 regulatory complexes via an overlapping nuclear matrix targeting signal/Smad interacting domain sequence (391–432) in Runx2. To establish the contribution...

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Autores principales: Javed, Amjad, Afzal, Faiza, Bae, Jong-Sup, Gutierrez, Soraya, Zaidi, Kaleem, Pratap, Jitesh, van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.
Formato: Artigo
Lenguaje:Inglês
Publicado: S. Karger AG 2008
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Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701265/
https://ncbi.nlm.nih.gov/pubmed/18728344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000151719
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