Tumor infection by oncolytic reovirus primes adaptive anti-tumor immunity

PURPOSE: Early clinical trials are underway exploring the direct oncolytic potential of reovirus. This study addresses whether tumor infection by reovirus is also able to generate bystander, adaptive anti-tumor immunity. EXPERIMENTAL DESIGN: Reovirus was delivered iv. to C57Bl/6 mice bearing lymph n...

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Main Authors: Prestwich, RJ, Errington, F, Ilett, EJ, Morgan, R, Scott, K, Kottke, T, Thompson, J, Morrison, EE, Harrington, KJ, Pandha, HS, Selby, PJ, Vile, RG, Melcher, AA
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701231/
https://ncbi.nlm.nih.gov/pubmed/19010851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0831
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