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Aberrant hyperactivation of Akt and mammalian target of rapamycin complex 1 (mTORC1) signaling in sporadic chordomas
STATEMENT OF TRANSLATIONAL RELEVANCE: Inhibitors of mammalian target of rapamycin complex 1 (mTORC1), such as rapamycin and its analogues, are currently being tested in clinical trial for TSC as well as many human cancers, which display hyperactivated mTORC1 signaling. mTORC1 has emerged as a critic...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701205/ https://ncbi.nlm.nih.gov/pubmed/19276265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2364 |
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