Aberrant hyperactivation of Akt and mammalian target of rapamycin complex 1 (mTORC1) signaling in sporadic chordomas

STATEMENT OF TRANSLATIONAL RELEVANCE: Inhibitors of mammalian target of rapamycin complex 1 (mTORC1), such as rapamycin and its analogues, are currently being tested in clinical trial for TSC as well as many human cancers, which display hyperactivated mTORC1 signaling. mTORC1 has emerged as a critic...

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Hauptverfasser: Han, Sangyeul, Polizzano, Carolyn, Nielsen, Gunnlaugur P., Hornicek, Francis J., Rosenberg, Andrew E., Ramesh, Vijaya
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701205/
https://ncbi.nlm.nih.gov/pubmed/19276265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2364
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