Chromosomal translocations induced at specified loci in human stem cells

The precise genetic manipulation of stem and precursor cells offers extraordinary potential for the analysis, prevention, and treatment of human malignancies. Chromosomal translocations are hallmarks of several tumor types where they are thought to have arisen in stem or precursor cells. Although ap...

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Bibliographic Details
Main Authors: Brunet, Erika, Simsek, Deniz, Tomishima, Mark, DeKelver, Russell, Choi, Vivian M., Gregory, Philip, Urnov, Fyodor, Weinstock, David M., Jasin, Maria
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700748/
https://ncbi.nlm.nih.gov/pubmed/19549848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902076106
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