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Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70
Chromosomal translocations in lymphoid tumours can involve antigen-receptor loci undergoing V(D)J recombination. Here, we show that translocations are recovered from the joining of RAG-generated double-strand breaks (DSBs) on one chromosome to an endonuclease-generated DSB on a second chromosome, pr...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3065497/ https://ncbi.nlm.nih.gov/pubmed/17643113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1624 |
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