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Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70

Chromosomal translocations in lymphoid tumours can involve antigen-receptor loci undergoing V(D)J recombination. Here, we show that translocations are recovered from the joining of RAG-generated double-strand breaks (DSBs) on one chromosome to an endonuclease-generated DSB on a second chromosome, pr...

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Sonraí Bibleagrafaíochta
Main Authors: Weinstock, David M., Brunet, Erika, Jasin, Maria
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065497/
https://ncbi.nlm.nih.gov/pubmed/17643113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1624
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