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Chromosomal translocations induced at specified loci in human stem cells

The precise genetic manipulation of stem and precursor cells offers extraordinary potential for the analysis, prevention, and treatment of human malignancies. Chromosomal translocations are hallmarks of several tumor types where they are thought to have arisen in stem or precursor cells. Although ap...

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Autors principals: Brunet, Erika, Simsek, Deniz, Tomishima, Mark, DeKelver, Russell, Choi, Vivian M., Gregory, Philip, Urnov, Fyodor, Weinstock, David M., Jasin, Maria
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700748/
https://ncbi.nlm.nih.gov/pubmed/19549848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902076106
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