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Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA)

In most human somatic cells, telomeres shorten as a function of DNA replication. Telomere length is therefore an indirect measure of the replicative history of cells. We measured the telomere lengths at XpYp chromosomes in purified human hematopoietic populations enriched for stem cells (Lin(−)CD34(...

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Main Authors: Hills, Mark, Lücke, Kai, Chavez, Elizabeth A., Eaves, Connie J., Lansdorp, Peter M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700317/
https://ncbi.nlm.nih.gov/pubmed/19359409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-198374
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