Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA)

In most human somatic cells, telomeres shorten as a function of DNA replication. Telomere length is therefore an indirect measure of the replicative history of cells. We measured the telomere lengths at XpYp chromosomes in purified human hematopoietic populations enriched for stem cells (Lin(−)CD34(...

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Главные авторы: Hills, Mark, Lücke, Kai, Chavez, Elizabeth A., Eaves, Connie J., Lansdorp, Peter M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2009
Предметы:
Hematopoiesis and Stem Cells
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700317/
https://ncbi.nlm.nih.gov/pubmed/19359409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-198374
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