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Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A
Pregnancy-associated plasma protein A (PAPPA) is a metalloproteinase that controls the tissue availability of insulin-like growth factor (IGF). Homozygous deletion of PAPPA in mice leads to lifespan extension. Since immune function is an important determinant of individual fitness, we examined the n...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2700140/ https://ncbi.nlm.nih.gov/pubmed/19549878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807025106 |
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