Longevity and Age-Related Pathology of Mice Deficient in Pregnancy-Associated Plasma Protein-A

The pregnancy-associated plasma protein-A knockout (PAPP-A KO) mouse is a model of reduced local insulin-like growth factor (IGF)-I activity with normal circulating IGF-I levels. In this study, PAPP-A KO mice had significantly increased mean (27%), median (27%), and maximum (35%) life span compared...

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Hlavní autoři: Conover, Cheryl A., Bale, Laurie K., Mader, Jessica R., Mason, Megan A., Keenan, Kevin P., Marler, Ronald J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
Journal of Gerontology: BIOLOGICAL SCIENCES
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869530/
https://ncbi.nlm.nih.gov/pubmed/20351075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glq032
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