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Longevity and Age-Related Pathology of Mice Deficient in Pregnancy-Associated Plasma Protein-A
The pregnancy-associated plasma protein-A knockout (PAPP-A KO) mouse is a model of reduced local insulin-like growth factor (IGF)-I activity with normal circulating IGF-I levels. In this study, PAPP-A KO mice had significantly increased mean (27%), median (27%), and maximum (35%) life span compared...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2869530/ https://ncbi.nlm.nih.gov/pubmed/20351075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glq032 |
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