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Rapid Identification of Enzyme Variants for Reengineered Alkaloid Biosynthesis in Periwinkle

Monoterpene indole alkaloids from Catharanthus roseus (Madagascar periwinkle), such as the anticancer agents vinblastine and vincristine, have important pharmacological activities. Metabolic engineering of alkaloid biosynthesis can provide an efficient and environmentally friendly route to analogs o...

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Main Authors: Bernhardt, Peter, McCoy, Elizabeth, O’Connor, Sarah E.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700010/
https://ncbi.nlm.nih.gov/pubmed/17719488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.07.008
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