Substrate Specificity and Diastereoselectivity of Strictosidine Glucosidase, a Key Enzyme in Monoterpene Indole Alkaloid Biosynthesis

Strictosidine glucosidase (SGD) from Catharanthus roseus catalyzes the deglycosylation of strictosidine, an intermediate from which thousands of monoterpene indole alkaloids are derived. The steady state kinetics of SGD with a variety of strictosidine analogs revealed the substrate preferences of th...

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Bibliographic Details
Main Authors: Yerkes, Nancy, Wu, Jia, McCoy, Elizabeth, Galan, M. Carmen, Chen, Shi, O’Connor, Sarah E.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474460/
https://ncbi.nlm.nih.gov/pubmed/18061449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.11.063
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