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Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis

Biosynthetic pathways can be hijacked to yield novel compounds by introduction of novel starting materials. Here we have altered tryptamine, which serves as the starting substrate for a variety of alkaloid biosynthetic pathways, by replacing the indole with one of four aza-indole isomers. We show th...

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Autors principals: Lee, Hyang-Yeol, Yerkes, Nancy, O’Connor, Sarah E.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807416/
https://ncbi.nlm.nih.gov/pubmed/20064432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.11.016
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