An Extended Structure of the APOBEC3G Catalytic Domain Suggests a Unique Holoenzyme Model

Human APOBEC3G (A3G) belongs to a family of polynucleotide cytidine deaminases. This family includes APOBEC1 and AID, which edit APOB mRNA and antibody gene DNA, respectively. A3G deaminates cytidines to uridines in single-strand DNA and inhibits the replication of HIV-1, other retroviruses and retr...

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Autors principals: Harjes, Elena, Gross, Phillip J., Chen, Kuan-Ming, Lu, Yongjian, Shindo, Keisuke, Nowarski, Roni, Gross, John D., Kotler, Moshe, Harris, Reuben S., Matsuo, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700007/
https://ncbi.nlm.nih.gov/pubmed/19389408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.04.031
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