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Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G
APOBEC3G is a single-strand DNA cytosine deaminase capable of blocking retrovirus and retrotransposon replication. APOBEC3G has two conserved zinc-coordinating motifs but only one is required for catalysis. Here, deletion analyses revealed that the minimal catalytic domain consists of residues 198-3...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014798/ https://ncbi.nlm.nih.gov/pubmed/17869248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.08.076 |
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