Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G

APOBEC3G is a single-strand DNA cytosine deaminase capable of blocking retrovirus and retrotransposon replication. APOBEC3G has two conserved zinc-coordinating motifs but only one is required for catalysis. Here, deletion analyses revealed that the minimal catalytic domain consists of residues 198-3...

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Bibliographic Details
Main Authors: Chen, Kuan-Ming, Martemyanova, Natalia, Lu, Yongjian, Shindo, Keisuke, Matsuo, Hiroshi, Harris, Reuben S.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014798/
https://ncbi.nlm.nih.gov/pubmed/17869248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.08.076
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