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An Extended Structure of the APOBEC3G Catalytic Domain Suggests a Unique Holoenzyme Model
Human APOBEC3G (A3G) belongs to a family of polynucleotide cytidine deaminases. This family includes APOBEC1 and AID, which edit APOB mRNA and antibody gene DNA, respectively. A3G deaminates cytidines to uridines in single-strand DNA and inhibits the replication of HIV-1, other retroviruses and retr...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2700007/ https://ncbi.nlm.nih.gov/pubmed/19389408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.04.031 |
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