Synthesis of Symmetrical C- and Pseudo-symmetrical O-Linked Disaccharide Analogs for Arabinosyltransferase Inhibitory Activity in Mycobacterium tuberculosis

Herein we report the synthesis of symmetrical C-linked and pseudo-symmetrical O-linked disaccharides structurally related to Araf motifs present in the cell wall of MTB. Their activity in a competition-based arabinosyltransferase assay using [(14)C]-DPA as the glycosyl donor is also presented. In ad...

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Detalhes bibliográficos
Main Authors: Pathak, Ashish K., Pathak, Vibha, Riordan, James R., Suling, William J., Gurcha, Sudagar S., Besra, Gurdyal S., Reynolds, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699574/
https://ncbi.nlm.nih.gov/pubmed/17566735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.05.099
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