Indoleamine 2,3-dioxygenase controls conversion of Foxp3(+) Tregs to TH17-like cells in tumor-draining lymph nodes

The immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by a subset of murine plasmacytoid DCs (pDCs) in tumor-draining lymph nodes (TDLNs), where it can potently activate Foxp3(+) regulatory T cells (Tregs). We now show that IDO functions as a molecular switch in TDLNs, maintaini...

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Autori principali: Sharma, Madhav D., Hou, De-Yan, Liu, Yanjun, Koni, Pandelakis A., Metz, Richard, Chandler, Phillip, Mellor, Andrew L., He, Yukai, Munn, David H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2009
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699232/
https://ncbi.nlm.nih.gov/pubmed/19366986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-195354
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