Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

One mechanism contributing to immunologic unresponsiveness toward tumors may be presentation of tumor antigens by tolerogenic host APCs. We show that mouse tumor-draining LNs (TDLNs) contained a subset of plasmacytoid DCs (pDCs) that constitutively expressed immunosuppressive levels of the enzyme in...

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Udgivet i:J Clin Invest
Main Authors: Munn, David H., Sharma, Madhav D., Hou, Deyan, Baban, Babak, Lee, Jeffrey R., Antonia, Scott J., Messina, Jane L., Chandler, Phillip, Koni, Pandelakis A., Mellor, Andrew L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC449750/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15254595/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI21583
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