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Molecular Dynamics of Water Mediated Interactions of a Linear Benzimidazole-Biphenyl Diamidine with the DNA Minor Groove

DB921 has a benzimidazole-biphenyl system with terminal amidines that gives the compound a linear conformation with a radius of curvature that does not match the DNA minor groove shape. Surprisingly, the compound binds in the groove with an unusually high equilibrium constant [Miao, Y.; Lee, M. P. H...

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Detalhes bibliográficos
Main Authors: Athri, Prashanth, Wilson, W. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698132/
https://ncbi.nlm.nih.gov/pubmed/19445463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja809249h
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