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PAK signaling regulates oxidant-dependent NF-κB activation by flow
Disturbed blood flow promotes atherosclerosis mainly by inducing inflammatory gene expression in endothelial cells. Flow stimulates the proinflammatory transcription factor NF-κB through integrin- and Rac-dependent production of reactive oxygen species (ROS). Previous work demonstrated that NF-κB ac...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2697905/ https://ncbi.nlm.nih.gov/pubmed/18669917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.182097 |
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