PAK signaling regulates oxidant-dependent NF-κB activation by flow

Disturbed blood flow promotes atherosclerosis mainly by inducing inflammatory gene expression in endothelial cells. Flow stimulates the proinflammatory transcription factor NF-κB through integrin- and Rac-dependent production of reactive oxygen species (ROS). Previous work demonstrated that NF-κB ac...

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Bibliographic Details
Main Authors:	Orr, A. Wayne, Hahn, Cornelia, Blackman, Brett R., Schwartz, Martin Alexander
Format:	Artigo
Language:	Inglês
Published:	2008
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2697905/ https://ncbi.nlm.nih.gov/pubmed/18669917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.182097
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PAK signaling regulates oxidant-dependent NF-κB activation by flow

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