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Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase
Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh(−/−)) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with subsequent development of glomerulonephritis with...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Pergamon Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2697322/ https://ncbi.nlm.nih.gov/pubmed/19411110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2009.03.030 |
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