Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase

Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh(−/−)) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with subsequent development of glomerulonephritis with...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Paixão-Cavalcante, Danielle, Hanson, Steven, Botto, Marina, Cook, H. Terence, Pickering, Matthew C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Pergamon Press 2009
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697322/
https://ncbi.nlm.nih.gov/pubmed/19411110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2009.03.030
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