Mechanism of the Orotidine 5’-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization

The reaction catalyzed by orotidine 5’-monophosphate decarboxylase (OMPDC) involves a stabilized anionic intermediate, although the structural basis for the rate acceleration (k(cat)/k(non), 7.1 × 10(16)) and proficiency [(k(cat)/K(M))/k(non), 4.8 × 10(22) M(−1)] is uncertain. That the OMPDCs from M...

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Main Authors: Chan, Kui K., Wood, B. McKay, Fedorov, Alexander A., Fedorov, Elena V., Imker, Heidi J., Amyes, Tina L., Richard, John P., Almo, Steven C., Gerlt, John A.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697262/
https://ncbi.nlm.nih.gov/pubmed/19435314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900623r
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