Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome

Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant or spontaneous disorder characterized by multiple cutaneous basal cell carcinomas, odontogenic keratocysts, skeletal anomalies and facial dysmorphology, including cleft lip and palate. Causative mutations for NBCCS occur in the PT...

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Main Authors: Cobourne, Martyn T., Xavier, Guilherme M., Depew, Michael, Hagan, Louise, Sealby, Jane, Webster, Zoe, Sharpe, Paul T.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696601/
https://ncbi.nlm.nih.gov/pubmed/19394325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2009.04.021
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