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Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome

Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant or spontaneous disorder characterized by multiple cutaneous basal cell carcinomas, odontogenic keratocysts, skeletal anomalies and facial dysmorphology, including cleft lip and palate. Causative mutations for NBCCS occur in the PT...

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Detalhes bibliográficos
Main Authors: Cobourne, Martyn T., Xavier, Guilherme M., Depew, Michael, Hagan, Louise, Sealby, Jane, Webster, Zoe, Sharpe, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696601/
https://ncbi.nlm.nih.gov/pubmed/19394325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2009.04.021
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