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Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog

Holoprosencephaly (HPE) is a clinically heterogeneous developmental anomaly affecting the CNS and face, in which the embryonic forebrain fails to divide into distinct halves. Numerous genetic loci and environmental factors are implicated in HPE, but mutation in the sonic hedgehog (Shh) gene is an es...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Seppala, Maisa, Depew, Michael J., Martinelli, David C., Fan, Chen-Ming, Sharpe, Paul T., Cobourne, Martyn T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868789/
https://ncbi.nlm.nih.gov/pubmed/17525797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32032
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