Validation of a sensitive LC-MS assay for quantification of glyburide and its metabolite 4-transhydroxy glyburide in plasma and urine: an OPRU Network study

Glyburide (glibenclamide, INN), a second generation sulfonylurea is widely used in the treatment of gestational diabetes mellitus (GDM). None of the previously reported analytical methods provide adequate sensitivity for the expected sub-nanogram/mL maternal and umbilical cord plasma concentrations...

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Hlavní autoři: Naraharisetti, Suresh Babu, Kirby, Brian J., Hebert, Mary F., Easterling, Thomas R., Unadkat, Jashvant D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696259/
https://ncbi.nlm.nih.gov/pubmed/17980680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2007.10.010
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