Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells

PURPOSE: ABCG2 overexpression has been linked to resistance to topoisomerase inhibitors, leading us to examine the potential interaction between ABCG2 and becatecarin. METHODS: Interaction with ABCG2 was determined by ATPase assay, competition of [(125)I]iodoarylazidoprazosin (IAAP) photolabeling an...

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Hauptverfasser: Robey, Robert W., Obrzut, Tomasz, Shukla, Suneet, Polgar, Orsolya, Macalou, Sira, Bahr, Julian C., Di Pietro, Attilio, Ambudkar, Suresh V., Bates, Susan E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693460/
https://ncbi.nlm.nih.gov/pubmed/19132374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-008-0908-2
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